Mike Napoli hit a two-run homer and drove in three runs to help the Boston Red Sox wrap up their first winning road trip of more than three games this season with a 5-4 win over the Cincinnati Reds on Wednesday. Up next was Napoli, who went deep for the 15th time this season. A fielder's choice grounder by Napoli scored Nava. The blast by Napoli snapped a 3-3 tie and put Boston ahead for good in the finale of an eight-game road trip. Right-hander Anthony Ranaudo became the first Boston rookie to start his career 2-0 since Justin Masterson won his first three in 2008 and the Red Sox finished their eight-game trip with five wins. Burke Badenhop and Junichi Tazawa each pitched one perfect inning before Edward Mujica overcame back-to-back leadoff singles in the ninth for his third save.